Largest global COVID-19 vaccine safety study links vaccines to neurological, blood and heart-related conditions

A new study reveals a link between Wuhan coronavirus (COVID-19) vaccines and small increases in neurological, blood and heart-related conditions.

The largest global COVID-19 vaccine safety study to date, conducted by the Global Vaccine Data Network and published in the journal Vaccine, analyzed data from 99 million vaccinated people in eight countries, looking for 13 medical conditions considered “adverse events of special interest.”

According to the study, individuals who received first to third doses of mRNA vaccines, including those from Pfizer Inc., BioNTech SE and Moderna Inc., had a higher risk of myocarditis, an inflammation of the heart muscle. The highest increase was observed after a second dose of the Moderna shot. Additionally, the first and fourth doses of the same vaccine were linked to an increase in pericarditis, or inflammation of the thin sac covering the heart. (Related: Study: Nearly two-thirds of COVID-19 vaccine recipients suffer from health complications a year later.)

Meanwhile, viral-vector vaccines, such as the one developed by the University of Oxford and manufactured by AstraZeneca Plc, were associated with an elevated risk of blood clots in the brain.

The researchers also discovered a notable rise in Guillain-Barre syndrome – a neurological disorder where the immune system attacks the peripheral nervous system – within 42 days after people receive the Oxford-developed ChAdOx1 or “Vaxzevria” vaccine, which was not observed with mRNA vaccines. The expected number of cases based on the background incidence was 66, but they observed 190 cases. Researchers found a threefold increase in cerebral venous sinus thrombosis after the ChAdOx1 vaccination, leading to the restriction of COVID-19 in several countries.

Moreover, the study found safety signals for transverse myelitis (spinal cord inflammation) and acute disseminated encephalomyelitis (inflammation and swelling in the brain and spinal cord) after both viral vector and mRNA vaccinations. Seven cases of acute disseminated encephalomyelitis were observed after the Pfizer-BioNTech vaccination, compared to the expected two.

Doctors still say COVID-19 vaccines are safe and effective despite evidence to the contrary

Despite their links to adverse effects, doctors continue to float COVID-19 vaccines as safe and effective.

For instance, Marc Siegel, a clinical professor of medicine at New York University Langone Medical Center, argues that all vaccines have side effects so the least that doctors and patients can do is carefully weigh the risks and benefits of COVID-19 vaccines.

“The massive study and review of the data reveals some rare association of the MRNA vaccines and myocarditis, especially after the second shot, as well as an association between the Oxford Astra Zeneca adenovirus vector vaccines and Guillain Barre syndrome,” he said. “But these risks are rare, and other studies show that the vaccine decreases the risk of myocarditis from COVID itself dramatically.”

“It always comes down to a risk-benefit analysis of what you are more afraid of – the vaccine’s side effects or the virus itself, which can have long-term side effects in terms of brain fog, fatigue, cough and also heart issues,” continued Siegel. “Denying or exaggerating a vaccine’s side effects is not good science, nor is underestimating the risks of the virus, especially in high-risk groups. This study does not really change anything; it just provides much further evidence of what we already know.”

Visit for more stories about the side effects of COVID-19 vaccines.

Watch U.K. Member of Parliament Andrew Bridgen calling for the suspension of mRNA COVID-19 vaccines in the House of Commons.

This video is from the channel The Big Logic channel on

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